GK087 ScienCell 人類染色質(zhì)組織和重塑qPCR檢測試劑盒，Human Chromatin Organization and Remodeling qPCR Array Kit

ScienCell 研究實驗室（ScienCell）是一家生物技術(shù)公司，其使命是實驗和治療用細(xì)胞和細(xì)胞相關(guān)產(chǎn)品的研究和發(fā)展。 ScienCell為研究界提供各種高質(zhì)量的正常的人類和動物細(xì)胞，細(xì)胞培養(yǎng)基和試劑，培養(yǎng)基添加因子，細(xì)胞來源的RNA，cDNA和蛋白質(zhì)。ScienCell的科學(xué)家們以改善生活質(zhì)量，實現(xiàn)細(xì)胞的能力，打擊人類退化性疾病為目的研究和開發(fā)各種細(xì)胞治療策略。ScienCell總部設(shè)在美國加利福尼亞州圣地亞哥，公司成立于1999年。

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GK087 ScienCell人類染色質(zhì)組織和重塑qPCR檢測試劑盒，Human Chromatin Organization and Remodeling qPCR Array Kit，產(chǎn)品簡介：

產(chǎn)品品牌： ScienCell

產(chǎn)品貨號：GK087

產(chǎn)品名稱：GK087 ScienCell人類染色質(zhì)組織和重塑qPCR檢測試劑盒，Human Chromatin Organization and Remodeling qPCR Array Kit

產(chǎn)品規(guī)格：One 96-well plate, one 20ul reaction per well

GK087 ScienCell人類染色質(zhì)組織和重塑qPCR檢測試劑盒，Human Chromatin Organization and Remodeling qPCR Array Kit， 產(chǎn)品說明：

ScienCell的GeneQuery™人類染色質(zhì)組織和重塑qPCR陣列試劑盒（GQH-CHM）分析了88個參與調(diào)節(jié)染色質(zhì)結(jié)構(gòu)的關(guān)鍵基因。 染色質(zhì)壓縮DNA，允許有絲分裂，同時防止DNA損傷和控制基因表達。 它是一種復(fù)雜的大分子，僅在由RNA，DNA和蛋白質(zhì)組成的真核生物中發(fā)現(xiàn)。 染色質(zhì)的基本蛋白質(zhì)是組蛋白，組蛋白修飾有助于改變?nèi)旧|(zhì)堆積和結(jié)構(gòu)。 如何根據(jù)其功能對所包含的基因進行分組的簡要示例如下所示：

染色質(zhì)重塑：ATRX，CBX2，CREBBP，EP300，MECOM

染色質(zhì)組織：HIST1H3A，HIST1H3J，HIST2H3A，HIST2H3D，HIST3H3

組蛋白乙酰化/去乙?；?span>ELP3、HDAC1、HDAC4、JADE2、KAT6A

組蛋白甲基化/去甲基化：DNMT3A、DOT1L、EZH2、JMJD6、KDM6A

GeneQuery™ qPCR 芯片試劑盒采用 96 孔板格式的 qPCR 就緒，每個孔包含一個引物組，可識別并有效擴增特定靶基因的 cDNA。精心設(shè)計的引物確保：（i）qPCR分析中的優(yōu)良退火溫度為65°C（含2 mM Mg2+且不含DMSO）;（ii）除非另有說明，否則引物集可識別靶基因的所有已知轉(zhuǎn)錄本變體;（iii）只有一個基因被擴增。每個引物組都已通過qPCR和熔解曲線分析和凝膠電泳進行了驗證。

ScienCell's GeneQuery™ Human Chromatin Organization and Remodeling qPCR Array Kit (GQH-CHM) profiles 88 key genes involved in regulating chromatin structure.  Chromatin compacts DNA, allowing mitosis while preventing DNA damage and controlling gene expression.  It is a complex macromolecule that is only found in eukaryotes consisting of RNA, DNA, and protein.  The basic proteins of chromatin are histones and histone modifications contribute to altering chromatin packing and structure.  Brief examples of how included genes may be grouped according to their function are shown below:

·         Chromatin remodeling: ATRX, CBX2, CREBBP, EP300, MECOM

·         Chromatin organization: HIST1H3A, HIST1H3J, HIST2H3A, HIST2H3D, HIST3H3

·         Histone acetylation/deacetylation: ELP3, HDAC1, HDAC4, JADE2, KAT6A

·         Histone methylation/demethylation: DNMT3A, DOT1L, EZH2, JMJD6, KDM6A

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that recognizes and efficiently amplifies a specific target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+and no DMSO); (ii) the primer set recognizes all known transcript variants of the target gene, unless otherwise noted; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis and gel electrophoresis.

GeneQuery™ 人類染色質(zhì)組織和重塑 qPCR 陣列板布局*（8 個粗體和斜體對照）

提示：基因選擇可能會根據(jù)新的研究和開發(fā)進行更新

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